Tag: blood

Coffee and Caffeine

Todays post is about coffee and caffeine.

Recently Scott came home from a day at university and declared he was giving up coffee, or to be more precise, caffeine. He explained that one of the lectures he attended was about the effects of caffeine on the body.

This was the start of several discussions and I wondered how much information was available on this subject.

A search of the Internet provides a massive amount on information about coffee and caffeine. Most is about how good it is. There is less information about any down sides.

First, what is Coffee?

Coffee beans are the seeds of a fruit called a coffee cherry. Coffee cherries grow on coffee trees from a genus of plants called ‘Coffea’. There are a wide variety of species of coffee plants, ranging from shrubs to trees.

Coffee beans start out green. They are roasted at a high heat to produce a chemical change that releases the rich aroma and flavour that we associate with coffee. They are then cooled and ground for brewing.

The result is an intricate mixture of more than a thousand chemicals. The cup of coffee you order from a coffee shop is likely different from the coffee you make at home.

About the caffeine

Caffeine is a psychoactive substance that occurs naturally in the fruit, leaves, and beans of coffee, cacao, and guarana plants. It is also added to some beverages and supplements.

It is absorbed within about 45 minutes after consuming, and peaks in the blood anywhere from 15 minutes to 2 hours. The caffeine in beverages is quickly absorbed in the gut. From there it dissolves into both the body’s water and fat molecules. It is then able to cross into the brain.

Food or food components, such as fibre, in the gut can delay how quickly caffeine in the blood peaks. It can remain in the blood anywhere from 1.5 to 9.5 hours, depending on various factors.

According to many studies, moderate intake can promote a variety of health benefits, including a lower risk of certain cancers, brain conditions, and liver problems.

Is caffeine bad for us?

Caffeine consumption also carries several risks and the human response to it can vary substantially across individuals. Low to moderate doses (50–300 mg) may cause increased alertness, energy, and ability to concentrate.

This is due to the caffeine increasing the neurotransmitters for memory, concentration and pleasure.

However, research has also linked moderate amounts of caffeine to adverse effects on health.

In 2013, the results of a study showed that consuming as much as 300 mg of caffeine a day during pregnancy may increase the risk of having a baby with low birth weight.

In 2015 a study identified several negative effects of consuming more than 400 mg of caffeine per day. The adverse effects include reduced blood flow to the brain and heart, irregular and/or rapid heart rate as well as reducing the body’s ability to recycle and absorb calcium.

Some symptoms of increased caffeine consumption include anxiety, restlessness, insomnia and tremors.

Interestingly, these effects can also be present when people withdraw from caffeine.

Then there was also a wide range of studies that suggested that the cognitive benefits of caffeine are actually associated with relief from withdrawal, rather than with improvement in function.

To drink coffee or not?

It appears that more research is necessary to confirm whether long-term caffeine consumption is safe. Whether it provides benefits or increases the risk of health problems. At the end of the day, it is how the individual feels when they do, or don’t drink coffee.

On a personal note Scott only drank, on average, 2 cups of coffee a day so he didn’t think that giving up coffee would be noticeable. However, on the day he decided to stop drinking coffee, he experienced headaches, was jittery and quite grumpy. Thankfully these symptoms only lasted one day.

Now Scott is drinking decaffeinated coffee. He states that he his head feels clearer with less brain fog and generally feels better overall.

Till the next post,

Live clean n Prosper.

Sources – US National Library of Medicine, Harvard School of Public Health, Science Direct, Medical News Today

A bit about Hemochromatosis

Todays post is about a condition called Hemochromatosis. A topic I was discussing recently with a colleague.

Interestingly, this condition is usually considered a blood disorder, however it seems a little more complicated than that.

So what is Hemochromatosis?

Also known as Inherited Iron Overload Disorder, is caused by gene mutations.
This means that usually hemochromatosis is hereditary. There are however, some cases where the condition can be a result of another illness.
Only a small number of people who have the gene mutation develop serious problems.

Our body has specific genes that regulate the absorption, transport and storage of iron. The mutated genes impair the intestines control of the absorption of iron from foods during digestion. They alter the distribution of the iron to other parts of the body. As a result, the amount of total body iron is increased.

Because the human body cannot increase the excretion of iron, the iron accumulates. Too much iron can be toxic and over time the buildup causes damage. The liver, heart, pancreas, endocrine glands, and joints are the organs most affected.

What are the symptoms?

Hereditary hemochromatosis is actually present at birth, however some people with the condition never have symptoms. Many early signs and symptoms often overlap with those of other common conditions.

Most people don’t experience signs and symptoms until later in life. Usually after the age of 40 in men and after age 60 in women. Women are more likely to develop symptoms after menopause. This is because they no longer lose iron with menstruation and pregnancy.

Early symptoms of the condition may include extreme tiredness and fatigue, joint pain, abdominal pain, weight loss, and loss of sex drive. As the condition worsens, affected individuals may develop arthritis, liver disease (cirrhosis) or liver cancer, diabetes, heart abnormalities, or skin discolouration.

Environmental and lifestyle factors such as the amount of iron in the diet, alcohol use, and other illnesses can affect the severity of the symptoms.

How is it treated?

Doctors diagnose hemochromatosis based on blood tests to check levels of iron and certain proteins in the blood. Followed by checks for gene mutations that commonly cause hemochromatosis. In some cases, doctors may also use a liver biopsy to confirm iron overload is present.

Treatment includes regularly removing blood from your body. Because much of the body’s iron is contained in the red blood cells, this treatment lowers iron levels.

The amount of blood removed and how often it’s removed depend on several factors. A persons age, overall health and the severity of iron overload all have an impact.

Dietary changes are also recommended to reduce iron intake. Within our diet we consume two types of iron: heme iron, which is contained in meat and non-heme iron, which is contained in plants and supplements. Heme iron is the most easily absorbed, whereas non-heme is absorbed less well.
Calcium is the only known substance that can impair the absorption of both heme and non-heme iron. Whereas eggs, fibre and the tannins found in coffee, tea and chocolate impair absorption of non-heme iron.

Recommended dietary changes can include:

  •  avoiding supplements that contain iron and vitamin C
  •  reducing iron-rich and iron-fortified foods
  •  reduce red meat intake
  •  alcohol intake,
  •  avoiding uncooked fish and shellfish

If you’re concerned about your iron levels, reach out to your doctor and start with a blood test.

I hope that you found this information interesting.

Till the next post,

Live clean n Prosper

Sources – U.S. National Library of Medicine,
Mayo Clinic, Davidson’s Principles & Practice of Medicine,
Haemochromatosis AustraliaOu-

Alcohol and the body.

Todays post is about how our body, or more specifically the liver, deals with alcohol.

Many of us indulge in an alcoholic beverage on a regular basis. Some people indulge more regularly and in greater quantities than others. Most of us know the basics of what happens in our bodies when we drink alcohol.

Scott has recently covered this subject in his studies and I thought it was interesting. I decided to learn more details and share this information.

How the alcohol is initially absorbed.

Alcohol absorption begins in the stomach. However, it is absorbed much more rapidly in the small intestine due to the larger surface area. So, the longer the alcohol remains in the stomach, the slower the rise in the blood alcohol level. Fatty acids slow down the movement of food through the stomach. Therefore the consumption of foods higher in fats will slow the rise of blood alcohol. This will also give time for the enzyme alcohol dehydrogenase (ADH) to start breaking down the alcohol.

Alcohol dehydrogenase is our primary defence against alcohol, a toxic molecule that compromises the function of our nervous system. The high levels of alcohol dehydrogenase in our liver and stomach detoxify about one drink (10grams of alcohol) each hour.

Once the alcohol enters the blood stream, it goes directly from the digestive tract to the liver.

The science

In the liver there is more alcohol dehydrogenase to break down ethanol in the blood. The alcohol dehydrogenase breaks alcohol down into another compound, acetaldehyde. Next, another enzyme, called aldehyde dehydrogenase (ALDH) breaks it down further into acetate, another metabolite.

This can then be converted to Acetyl coenzyme A, (acetyl-CoA), an important molecule used in metabolic processes. It is primarily used by the body for energy production and is an essential component in balancing carbohydrate and fat metabolism

 What does this mean?

On those occasions when we consume alcoholic beverages while eating pizza and deep fried foods, followed by cake and ice cream, the body deals with the alcohol first.

This is because the liver recognises the alcohol as the most toxic substance in the body at the time.

So while the liver is dealing with the alcohol, the fats and sugars are getting pushed into the blood stream to wait. This also means that the liver will first break down the alcoholic beverage into its main components and then dealing with the alcohol first.

The liver requires certain essential nutrients from the body to do its job. It also works through the toxins in 2 phases. If there are not enough nutrients available for the liver to do its job, this causes the by-products to hang around for a lot longer in between the phases. This can then cause other issues.

 Supporting the liver

It is possible to provide support to the liver so that it can metabolise alcohol more effectively, therefore reducing long-term damage.

The 2 phases of detoxification require different nutrients.

Phase 1 requires B group vitamins, Folic acid, Glutathione, Antioxidants, Carotenoids, vitamins E and vitamin C.

Phase 2 requires Amino Acids (Glutamine, Glycine, Taurine & Cystine) and sulphurated phytochemicals found in garlic and cruciferous vegetables (broccoli, cauliflower, cabbage & Brussels sprouts)

There are also certain compounds available that may be helpful.

  • Grape seed extract is a well-known antioxidant that assists liver function.
  • Grapefruit seed extract increases gastric protection
  • Vitamin C
  • Zinc
  • Curcumin (found in Turmeric)

Current Australian health guidelines state “For healthy men and women, drinking no more than two standard drinks on any day reduces the lifetime risk of harm from alcohol-related disease or injury.” (NHMRC 2009) Sources – Principles of Anatomy & Physiology by Gerard J Totora/Bryan Derrickson, https://en.wikipedia.org, https://pdb101.rcsb.org

With this in mind, a good diet consisting of whole, unprocessed foods goes a long way in supporting the liver. Many of the nutrients essential for optimal liver function are found in fresh fruit and vegetables.

I hope you found this information interesting.

Till the next post,

Live clean n prosper